Investigating how ALS-related proteins behave in different conditions
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
This study is looking at how specific proteins related to ALS behave and change, which could help us find new ways to slow down the disease and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11013385 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain proteins associated with Amyotrophic Lateral Sclerosis (ALS) behave under various conditions, particularly how they form structures called stress granules. These stress granules can change from a liquid-like state to a solid state due to mutations, which may contribute to the progression of ALS. By studying the physical properties of these proteins, the research aims to uncover potential therapeutic targets that could slow down or alter the disease's progression. Patients may benefit from insights gained about the mechanisms behind ALS and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis or those at risk due to genetic factors.
Not a fit: Patients with other neurodegenerative diseases not related to ALS may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that slow the progression of ALS.
How similar studies have performed: Other research has shown promise in understanding protein behavior in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mittag, Tanja — St. Jude Children's Research Hospital
- Study coordinator: Mittag, Tanja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.