Investigating how alpha-synuclein affects Parkinson's disease and dementia progression
α-Synuclein strain properties are associated with diagnosis of and progression to Parkinson's disease with dementia
This study is looking at how a protein linked to dementia affects memory and thinking in people with Parkinson's disease, hoping to find clues that could help improve treatments for those experiencing cognitive challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10611810 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of alpha-synuclein, a protein associated with dementia, in the progression of Parkinson's disease dementia (PDD). It aims to identify how the aggregation of this protein in the brain correlates with cognitive decline and other symptoms in patients with Parkinson's disease. By studying the pathological markers and their relationship to clinical presentations, the research seeks to uncover insights that could lead to better treatment options. Patients with varying stages of cognitive impairment related to Parkinson's disease may be involved in this research.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Parkinson's disease, particularly those experiencing cognitive impairment or dementia.
Not a fit: Patients with Parkinson's disease who do not exhibit any cognitive impairment or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapies for patients suffering from Parkinson's disease dementia.
How similar studies have performed: Previous research has shown promising results in understanding the role of alpha-synuclein in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mao, Xiaobo — Johns Hopkins University
- Study coordinator: Mao, Xiaobo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.