Investigating how alpha-synuclein affects neuron function and disease
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology
This study is looking at how a protein called alpha-synuclein affects brain cells and is linked to conditions like Parkinson's and Lewy body dementia, and it aims to see if making changes to this protein can help protect brain cells and improve their function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10904820 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of alpha-synuclein (aSyn) in neuron function and its connection to diseases like Parkinson's and Lewy body dementia. The study aims to explore how aSyn's binding to synaptic vesicles influences neuron survival and neurotransmitter release. By using specially designed variants of aSyn that enhance its binding to synaptic vesicles, researchers will assess whether this stabilization can reduce toxicity and improve neuronal health. The findings could provide insights into potential therapeutic strategies for synucleinopathies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or Lewy body dementia.
Not a fit: Patients with other neurological disorders unrelated to synucleinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect neurons and improve outcomes for patients with Parkinson's disease and related disorders.
How similar studies have performed: Previous research has shown promising results in targeting alpha-synuclein aggregation, indicating that this approach may hold potential for therapeutic advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Burre, Jacqueline — Weill Medical Coll of Cornell Univ
- Study coordinator: Burre, Jacqueline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.