Investigating how alpha-synuclein affects DNA repair and aging in cells.
Official title: The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence
Funded at Oregon Health & Science University · NIH-10934325 · Data updated 2026-11-12
This study is looking at how a protein called alpha-synuclein, which is connected to Parkinson's disease, helps repair DNA and affects how our cells age, with the hope of finding new ways to understand and treat both neurodegenerative diseases and cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AG082406-02 |
| Project ID | NIH-10934325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Parkinson's disease or melanoma, particularly those with a family history of these conditions.
✕Less likely to help
Patients with conditions unrelated to neurodegeneration or cancer may not receive any benefit from this research.
What this research studies
This research explores the role of alpha-synuclein, a protein linked to neurodegenerative diseases like Parkinson's, in the repair of DNA damage and the aging process of cells. By examining how this protein functions in both brain cells and melanoma cells, the study aims to uncover the cellular mechanisms that connect neurodegeneration and cancer. Patients may benefit from insights into how these diseases are related and potential new therapeutic targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases and cancers associated with aging.
How similar studies have gone: Previous research has shown promising results in understanding the role of alpha-synuclein in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
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Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Arnold, Moriah Rebecca — Oregon Health & Science University
- Study coordinator: Arnold, Moriah Rebecca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.