Investigating how allopregnanolone affects depression in perimenopausal women
Using allopregnanolone to probe behavioral and neurobiological mechanisms that underlie depression in women across perimenopausal stage
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10750968
This study is looking at how a natural hormone called allopregnanolone might help women who are feeling depressed during perimenopause, with the goal of finding new ways to improve their mood during this time of hormonal changes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10750968 on ClinicalTrials.gov |
What this research studies
This research explores the role of the neurosteroid allopregnanolone in treating depression specifically in women undergoing perimenopause. It aims to understand the behavioral and neurobiological mechanisms that contribute to depression during this hormonal transition. By conducting a placebo-controlled trial, the study will assess how allopregnanolone may alleviate symptoms of perimenopausal depression, potentially leading to new treatment options. The research is particularly focused on the hormonal changes that occur during this stage of life and their impact on mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing depression during the perimenopausal stage.
Not a fit: Patients who are not experiencing perimenopausal depression or those who are not women may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for perimenopausal depression, improving the quality of life for many women.
How similar studies have performed: Previous research has shown success with similar approaches in treating postpartum depression using allopregnanolone, suggesting potential for this novel application.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOFFE, HADINE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: JOFFE, HADINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders