Investigating how allergens trigger immune responses in asthma
Allergen-induced extracellular DNA in type 2 immunity
This study is looking at how things like allergens and air pollution affect the lungs in people with asthma and allergies, especially how certain cells release DNA that might influence the immune system, with the hope of finding new treatments that could help you breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10886710 on NIH RePORTER |
What this research studies
This research explores the immune mechanisms that lead to asthma and allergic airway diseases, particularly focusing on how allergens and environmental factors like air pollution affect the airway epithelium. The study examines how airway cells release DNA in response to allergens and how this release influences immune responses. By using both in vitro and in vivo models, the researchers aim to understand the role of extracellular DNA in promoting type 2 immunity, which is crucial for developing targeted therapies for asthma. Patients may benefit from insights gained into the underlying causes of their condition and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from asthma or allergic airway diseases, particularly those with known allergen sensitivities.
Not a fit: Patients with non-allergic respiratory conditions or those not affected by asthma or allergic responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing asthma and allergic diseases.
How similar studies have performed: Previous research has shown that understanding immune responses to allergens can lead to significant advancements in asthma treatment, indicating a promising avenue for this investigation.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Kita, Hirohito — Mayo Clinic Arizona
- Study coordinator: Kita, Hirohito
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.