Investigating how aldosterone affects kidney health and blood pressure during injury.
The function and regulation of intrarenal aldosterone synthase in ischemia-induced hypertension and renal injury
This study is looking at how a hormone called aldosterone affects blood pressure and kidney health, especially for people dealing with high blood pressure and kidney problems, to find new ways to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10805813 on NIH RePORTER |
What this research studies
This research focuses on the role of aldosterone, a hormone involved in regulating blood pressure, particularly in the context of kidney injury and hypertension. It aims to understand how aldosterone is produced within the kidneys and how its regulation can impact conditions like chronic kidney disease and resistant hypertension. By using a novel mouse model, researchers will explore the mechanisms that lead to increased aldosterone production during renal injury, potentially identifying new therapeutic targets. The findings could lead to better treatment options for patients suffering from hypertension and kidney-related issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hypertension, chronic kidney disease, or those experiencing renal injury.
Not a fit: Patients without hypertension or kidney-related conditions are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage hypertension and improve kidney health.
How similar studies have performed: Previous studies have shown promise in targeting aldosterone pathways for hypertension treatment, indicating potential for success in this research.
Where this research is happening
Salt Lake City, United States
- VA Salt Lake City Healthcare System — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Yang, Tianxin — VA Salt Lake City Healthcare System
- Study coordinator: Yang, Tianxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.