Investigating how aldosterone affects heart health in obese individuals
Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10906101
This study is looking at how a medication called eplerenone can help improve heart health in people with obesity who might also have high blood pressure or metabolic issues, and you'll either get eplerenone or a regular blood pressure medicine for a year to see which works better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10906101 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of aldosterone, a hormone that can contribute to heart disease, particularly in individuals with obesity. The study will involve participants who have obesity and may also have high blood pressure or metabolic syndrome features. Through advanced imaging techniques like cardiac MRI and detailed physiological assessments, researchers aim to evaluate how a specific medication, eplerenone, can improve heart function and reduce risks associated with cardiovascular disease. Participants will be randomly assigned to receive either eplerenone or a standard blood pressure medication for one year to compare outcomes.
Who could benefit from this research
Good fit: Ideal candidates are adults with obesity who also have untreated hypertension or features of metabolic syndrome.
Not a fit: Patients without obesity or those who do not have hypertension or metabolic syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and reduced cardiovascular risks for obese individuals.
How similar studies have performed: Previous research has shown that mineralocorticoid receptor antagonists can be effective in managing cardiovascular risks, suggesting a promising approach in this area.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAIDYA, ANAND — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: VAIDYA, ANAND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.