Investigating how alcohol use affects gene changes in the brain
Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder
This study is looking at how drinking too much alcohol affects the brain's RNA and gene activity, which could help us find new ways to understand and treat alcohol use disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10996153 on NIH RePORTER |
What this research studies
This research focuses on understanding the changes in RNA methylation in the brains of individuals with alcohol use disorder (AUD). By examining postmortem brain samples from various regions, the study aims to identify how chronic alcohol consumption alters gene expression and neuronal activity. The researchers will analyze the relationship between these epitranscriptomic changes and the development of AUD, potentially uncovering new mechanisms that contribute to addiction. This could lead to better understanding and treatment options for those affected by AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who have been diagnosed with alcohol use disorder.
Not a fit: Patients who do not have alcohol use disorder or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into new therapeutic targets for treating alcohol use disorder.
How similar studies have performed: While the specific focus on RNA methylation in AUD is relatively novel, previous research has shown that genetic and epigenetic changes play a significant role in addiction, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Huiping — Boston University Medical Campus
- Study coordinator: Zhang, Huiping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.