Investigating how alcohol exposure affects brain cells in a mouse model
Astrocyte gene expression and translation in an in vivo FASD mouse model
This study is looking at how drinking alcohol while developing can affect important brain cells called astrocytes, using mice to learn more about how these changes happen and what they mean for brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10908731 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of alcohol exposure during development on astrocytes, which are crucial brain cells. By using advanced techniques, the study aims to analyze changes in gene expression and protein translation in these cells in a mouse model. The researchers will employ methods like translating ribosome affinity purification and fluorescent-activated cell sorting to isolate and study astrocytes in vivo. This approach will help uncover the mechanisms by which alcohol affects brain function and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by fetal alcohol spectrum disorders or those with a history of developmental alcohol exposure.
Not a fit: Patients who have not been exposed to alcohol during development or do not have related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for conditions related to fetal alcohol spectrum disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in brain disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Guizzetti, Marina — Oregon Health & Science University
- Study coordinator: Guizzetti, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.