Investigating how alcohol dependence affects immune response in sepsis
Immuno-metabolic dysfunction in alcohol with sepsis
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10893494
This study is looking at how alcohol dependence affects the chances of surviving sepsis, a serious infection, by exploring how alcohol changes the body's immune response, with the hope of finding new treatments to help people who are struggling with both conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10893494 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between alcohol dependence and sepsis mortality, aiming to uncover the mechanisms behind this connection. It focuses on how ethanol impacts the immune response during sepsis, particularly the transition from a hyper-inflammatory to a hypo-inflammatory state. By using mouse models and cell cultures, the study examines the role of specific proteins, known as sirtuins, in regulating inflammation and immune function. The ultimate goal is to identify potential targeted treatments that could improve outcomes for patients suffering from sepsis related to alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol dependence who are at risk of developing sepsis.
Not a fit: Patients who do not have a history of alcohol dependence or those who are not at risk for sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates for patients with sepsis who have a history of alcohol dependence.
How similar studies have performed: Previous research has indicated that targeting immune responses in sepsis can lead to improved outcomes, suggesting that this approach may hold promise.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VACHHARAJANI, VIDULA — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: VACHHARAJANI, VIDULA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.