Investigating how alcohol causes inflammation in the brain and potential treatments for alcohol use disorder.
Alcohol-Induced Neuroinflammation and AUD Therapeutic Mechanisms
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11032818
This study is looking at how inflammation in the brain affects people with alcohol use disorder and is testing three potential new medications that might help reduce this inflammation and improve treatment for both occasional and dependent drinkers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11032818 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of neuroinflammation in alcohol use disorder (AUD) and aims to identify new medications that can effectively treat this condition. The researchers are exploring three candidate drugs that may reduce inflammation in the brain caused by alcohol consumption. By using animal models, they will test the effects of these drugs on both non-dependent and dependent alcohol use, aiming to uncover how inflammation contributes to AUD and how it can be targeted therapeutically.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder or those experiencing issues related to alcohol consumption.
Not a fit: Patients who do not have alcohol use disorder or are not affected by alcohol-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for individuals struggling with alcohol use disorder.
How similar studies have performed: Previous research has shown promise in targeting neuroinflammation for treating alcohol use disorder, suggesting that this approach may yield beneficial results.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANNA, PIETRO P — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: SANNA, PIETRO P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.