Investigating how alcohol and high-calorie diets affect liver function
Alcohol and calorie-dense diet-mediated hepatic mitochondrial dysregulation
This study is looking at how drinking alcohol and eating high-calorie foods can affect liver health, especially how they might harm the tiny powerhouses in liver cells, and it's aimed at helping people understand more about liver problems and potential treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11054673 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of alcohol consumption and calorie-dense diets on liver health, particularly how these factors disrupt mitochondrial function in liver cells. Using a preclinical macaque model and advanced cell culture techniques, the study aims to explore the mechanisms behind alcohol-related liver injury and the combined impact of diet on liver disease. By examining gene expression related to mitochondrial health, the research seeks to uncover critical insights that could inform future treatments for liver disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption and/or those who follow a calorie-dense diet, particularly those at risk for liver disease.
Not a fit: Patients who do not consume alcohol or have a healthy diet may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating liver diseases associated with alcohol and poor diet.
How similar studies have performed: Previous studies have shown that both alcohol and high-fat diets can negatively impact liver health, indicating that this research builds on established findings.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Gallegos, Eden Mcmillin — Lsu Health Sciences Center
- Study coordinator: Gallegos, Eden Mcmillin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.