Investigating how alcohol and high-calorie diets affect liver function
Official title: Alcohol and calorie-dense diet-mediated hepatic mitochondrial dysregulation
Funded at Lsu Health Sciences Center · NIH-11054673 · Data updated 2026-11-12
This study is looking at how drinking alcohol and eating high-calorie foods can affect liver health, especially how they might harm the tiny powerhouses in liver cells, and it's aimed at helping people understand more about liver problems and potential treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | April 17, 2023 |
| Project end | April 16, 2028 |
| Funding year | 2025 |
| Award (this year) | $41,391 |
| NIH project number | 5F30AA030910-03 |
| Project ID | NIH-11054673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol consumption and/or those who follow a calorie-dense diet, particularly those at risk for liver disease.
✕Less likely to help
Patients who do not consume alcohol or have a healthy diet may not benefit from this research.
What this research studies
This research focuses on understanding the effects of alcohol consumption and calorie-dense diets on liver health, particularly how these factors disrupt mitochondrial function in liver cells. Using a preclinical macaque model and advanced cell culture techniques, the study aims to explore the mechanisms behind alcohol-related liver injury and the combined impact of diet on liver disease. By examining gene expression related to mitochondrial health, the research seeks to uncover critical insights that could inform future treatments for liver disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating liver diseases associated with alcohol and poor diet.
How similar studies have gone: Previous studies have shown that both alcohol and high-fat diets can negatively impact liver health, indicating that this research builds on established findings.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Gallegos, Eden Mcmillin — Lsu Health Sciences Center
- Study coordinator: Gallegos, Eden Mcmillin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.