Investigating how alcohol affects the release of drugs from modified release formulations
Official title: Factors related to drug and Formulation affecting alcohol dose dumping in modified release oral drug products
Funded at Texas A&m University Health Science Ctr · NIH-11063608 · Data updated 2026-11-12
This study is looking at how drinking alcohol can unexpectedly cause some medications to be released too quickly, which can be dangerous, and it aims to find ways to make these medications safer for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,999 |
| NIH project number | 1U01FD008305-01 |
| Project ID | NIH-11063608 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are prescribed modified release medications, particularly those with a narrow therapeutic index.
✕Less likely to help
Patients who do not take modified release medications or those who do not consume alcohol may not benefit from this research.
What this research studies
This research focuses on understanding how alcohol can cause rapid and unintended release of medications from modified release oral drug products. It aims to identify the factors related to drug formulation that influence this phenomenon, known as dose dumping, which can lead to serious health risks such as overdose or sedation. By studying various drug formulations and their interactions with alcohol, the research seeks to improve the safety and efficacy of these medications. The findings could help in developing drug products that are less susceptible to dose dumping when consumed with alcohol.
Why it matters
Potential benefit: If successful, this research could lead to safer medication formulations that minimize the risk of overdose and adverse effects when taken with alcohol.
How similar studies have gone: While there is limited research on alcohol-induced dose dumping, understanding drug formulation interactions with alcohol is a novel area that has not been extensively studied.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Khan, Mansoor a — Texas A&m University Health Science Ctr
- Study coordinator: Khan, Mansoor a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.