Investigating how alcohol affects RNA modifications in liver disease
Official title: RNA Modification Changes in Alcohol-Associated Liver Disease
Funded at University of Louisville · NIH-10871387 · Data updated 2026-11-12
This study is looking at how drinking alcohol affects certain changes in RNA that might lead to liver problems, and it's being done with mice to help us understand more about alcohol-related liver disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,217 |
| NIH project number | 1R21AA031563-01 |
| Project ID | NIH-10871387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with varying stages of alcohol-associated liver disease.
✕Less likely to help
Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
What this research studies
This research explores the impact of alcohol consumption on RNA modifications that may contribute to the development and progression of alcohol-associated liver disease (ALD). By treating mice with alcohol and analyzing the changes in RNA chemical modifications, the study aims to uncover the mechanisms behind ALD. Researchers will isolate different types of RNA from mouse liver and use advanced techniques to detect specific modifications. The findings could provide insights into how alcohol alters RNA and its role in liver disease.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and potential treatments for patients suffering from alcohol-associated liver disease.
How similar studies have gone: While the specific approach of mapping RNA modifications in the context of alcohol consumption is novel, related research has shown promising results in understanding liver diseases.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: He, Liqing — University of Louisville
- Study coordinator: He, Liqing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.