Investigating how alcohol affects metabolism and esophageal health
Official title: NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
Funded at Coriell Institute for Medical Research · NIH-10893607 · Data updated 2026-11-12
This study is looking at how drinking alcohol affects metabolism and esophageal health, and it's for anyone interested in understanding the risks of alcohol on the esophagus, as researchers test ways to prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $589,786 |
| NIH project number | 5R01AA030026-04 |
| Project ID | NIH-10893607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol and may be at risk for esophageal conditions.
✕Less likely to help
Patients who do not consume alcohol or have no esophageal health concerns may not benefit from this research.
What this research studies
This research explores the role of the NRF2-ACSS2 axis in how alcohol consumption leads to changes in metabolism and esophageal health. By using both human cells and genetically modified mice, the researchers aim to understand the mechanisms behind alcohol-induced metabolic changes and their impact on the esophagus. The study involves testing the effects of specific inhibitors on these processes to potentially develop new preventive strategies against esophageal issues related to alcohol use.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures for esophageal problems caused by alcohol consumption.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways related to alcohol, suggesting potential for success in this area.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Chen, Xiaoxin Luke — Coriell Institute for Medical Research
- Study coordinator: Chen, Xiaoxin Luke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.