Investigating how alcohol affects metabolism and esophageal health
NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
['FUNDING_R01'] · CORIELL INSTITUTE FOR MEDICAL RESEARCH · NIH-10893607
This study is looking at how drinking alcohol affects metabolism and esophageal health, and it's for anyone interested in understanding the risks of alcohol on the esophagus, as researchers test ways to prevent these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORIELL INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (CAMDEN, UNITED STATES) |
| Trial ID | NIH-10893607 on ClinicalTrials.gov |
What this research studies
This research explores the role of the NRF2-ACSS2 axis in how alcohol consumption leads to changes in metabolism and esophageal health. By using both human cells and genetically modified mice, the researchers aim to understand the mechanisms behind alcohol-induced metabolic changes and their impact on the esophagus. The study involves testing the effects of specific inhibitors on these processes to potentially develop new preventive strategies against esophageal issues related to alcohol use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume alcohol and may be at risk for esophageal conditions.
Not a fit: Patients who do not consume alcohol or have no esophageal health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures for esophageal problems caused by alcohol consumption.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways related to alcohol, suggesting potential for success in this area.
Where this research is happening
CAMDEN, UNITED STATES
- CORIELL INSTITUTE FOR MEDICAL RESEARCH — CAMDEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, XIAOXIN LUKE — CORIELL INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: CHEN, XIAOXIN LUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.