Investigating how alcohol affects liver injury and disease progression
Official title: Alcohol-associated cholestatic liver injury and mechanisms
Funded at Tulane University of Louisiana · NIH-10929484 · Data updated 2026-11-12
This study is looking at how drinking alcohol affects the liver and makes it more vulnerable to serious damage, especially in people with alcohol-related liver disease, and it aims to find out more about this process using a special mouse model.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 14, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $140,905 |
| NIH project number | 5K01AA031305-02 |
| Project ID | NIH-10929484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with alcohol-associated hepatitis or those at risk of developing alcohol-related liver disease.
✕Less likely to help
Patients with liver diseases unrelated to alcohol consumption may not benefit from this research.
What this research studies
This research focuses on understanding the severe liver condition known as alcohol-associated hepatitis, which can be life-threatening and currently has few treatment options. The study aims to explore how alcohol consumption alters the liver environment, making it more susceptible to injury, particularly in the bile ducts. Using a novel mouse model, researchers will investigate the mechanisms behind cholestatic liver injury and its role in worsening alcohol-related liver disease. Various advanced techniques, including microbiome analysis and genetic studies, will be employed to uncover these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from alcohol-associated liver diseases.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding liver diseases related to alcohol consumption.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Yan, Shengmin — Tulane University of Louisiana
- Study coordinator: Yan, Shengmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.