Investigating how alcohol affects heart health through gut interactions
Official title: The role of gut-heart axis in acute alcohol intoxication-induced adverse cardiovascular events
Funded at Lsu Health Sciences Center · NIH-10903817 · Data updated 2026-11-12
This study is looking at how binge drinking affects heart health and aims to understand the connection between alcohol, the gut, and the heart, using mice to find out how certain substances in the body might impact heart function after drinking.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00AA028300-03 |
| Project ID | NIH-10903817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol, particularly those who engage in binge drinking behaviors.
✕Less likely to help
Patients who do not consume alcohol or have pre-existing severe cardiovascular conditions may not benefit from this research.
What this research studies
This research explores the connection between alcohol consumption and cardiovascular health, particularly focusing on how binge drinking can lead to serious heart issues. The study examines the role of the gut-heart axis and the activation of cannabinoid receptors in the heart following acute alcohol intoxication. By using a mouse model, researchers aim to identify the cellular sources of endocannabinoids and how they influence heart function after alcohol exposure. This could provide insights into the mechanisms behind alcohol-induced cardiovascular dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of heart problems related to alcohol consumption.
How similar studies have gone: Previous research has shown promising results in understanding the effects of alcohol on cardiovascular health, but this specific approach focusing on the gut-heart axis is relatively novel.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Paloczi, Janos — Lsu Health Sciences Center
- Study coordinator: Paloczi, Janos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.