Investigating how alcohol affects depression during withdrawal
Biochemical Studies Underlying Acute Ethanol's Antidepressant-like effects during Withdrawal in a Preclinical Model of Ethanol Dependence
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11036386
This study is looking at how drinking alcohol might briefly help with feelings of depression for people who struggle with both alcohol use and depression, and it aims to find new ways to help those individuals feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11036386 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between alcohol use disorder and major depressive disorder, focusing on how acute alcohol consumption can temporarily alleviate depressive symptoms. The study examines the biochemical mechanisms that lead to these effects, particularly during withdrawal from alcohol. By using preclinical models, researchers aim to understand how certain proteins in the brain change in response to alcohol and how these changes might influence mood and emotional states. The goal is to identify potential new treatments for individuals struggling with both alcohol dependence and depression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing both alcohol use disorder and symptoms of major depressive disorder.
Not a fit: Patients who do not have alcohol use disorder or major depressive disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating depression in individuals with alcohol use disorder.
How similar studies have performed: Previous research has shown promising results in understanding the biochemical pathways involved in alcohol's effects on mood, suggesting that this approach could yield valuable insights.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAAB-GRAHAM, KIMBERLY FRANCES — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: RAAB-GRAHAM, KIMBERLY FRANCES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.