Investigating how alcohol affects breast cancer stem cells
Project 3: Alcohol-Associated Toxicity and Genomic Instability of Mammary Stem Cells
['FUNDING_OTHER'] · NORTH CAROLINA CENTRAL UNIVERSITY · NIH-10897325
This study is looking at how drinking alcohol might affect certain cells in the breast and could lead to breast cancer, aiming to help us understand the connection between alcohol and cancer risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA CENTRAL UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10897325 on ClinicalTrials.gov |
What this research studies
This research explores the impact of alcohol consumption on mammary stem cells and its potential role in breast cancer development. It focuses on understanding how alcohol-derived acetaldehyde may cause genetic mutations and genomic instability in these cells, which could lead to cancer. By using advanced 3D cell culture techniques and animal models, the study aims to uncover the mechanisms behind alcohol-induced tumor initiation and the role of cancer stem cells in this process. The findings could provide insights into the relationship between alcohol consumption and breast cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are at risk for breast cancer.
Not a fit: Patients who do not consume alcohol or have no risk factors for breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for alcohol-related breast cancer.
How similar studies have performed: Previous studies have shown that alcohol can promote cancer stem cell expansion, indicating that this research builds on established findings.
Where this research is happening
DURHAM, UNITED STATES
- NORTH CAROLINA CENTRAL UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, XIAOHE — NORTH CAROLINA CENTRAL UNIVERSITY
- Study coordinator: YANG, XIAOHE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.