Investigating how airway cells contribute to chronic respiratory diseases
Non-Classical Cytokine Secretion in Chronic Airway Disease
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11146156
This study is looking at how certain cells in the airways of people with asthma and COPD release a substance called IL-33 that can cause inflammation, with the hope of finding new ways to treat these conditions and help patients breathe easier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11146156 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind chronic airway diseases like asthma and COPD. It aims to identify new therapeutic pathways by studying how diseased airway epithelial cells secrete a specific cytokine, IL-33, which plays a role in inflammation. The research utilizes both human clinical studies and animal models to explore how this cytokine is activated and secreted, potentially leading to new treatment options for patients. By uncovering these mechanisms, the study seeks to improve the understanding and management of chronic respiratory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from asthma or COPD, particularly those with severe or treatment-resistant forms of these conditions.
Not a fit: Patients with acute respiratory infections or those without chronic airway diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that modify the course of chronic airway diseases.
How similar studies have performed: Other research has shown promise in targeting cytokine pathways in chronic respiratory diseases, indicating that this approach may lead to significant advancements.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALEXANDER-BRETT, JENNIFER — WASHINGTON UNIVERSITY
- Study coordinator: ALEXANDER-BRETT, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease