Investigating how air pollution and genetics affect Alzheimer's disease
Official title: Aberrant protein S-nitrosylation mediates Gene-Environment Interactions in AD/ADRD
Funded at Scripps Research Institute, the · NIH-10973856 · Data updated 2026-11-12
This study is looking at how genes and things like air pollution might work together to affect brain health and lead to Alzheimer's disease, and it's for older adults who want to understand more about what influences memory and thinking problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $913,756 |
| NIH project number | 1U01AG088679-01 |
| Project ID | NIH-10973856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those with a genetic predisposition to Alzheimer's disease, such as carriers of the ApoE4 allele.
✕Less likely to help
Patients who are younger than 65 or do not have genetic risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the complex interactions between genetic factors, such as the ApoE4 gene, and environmental influences like air pollution in the development of Alzheimer's disease and related dementias. By examining how exposure to pollutants affects protein modifications in the brain, the study aims to uncover new therapeutic targets. Patients will be involved in understanding how these factors contribute to cognitive decline, particularly in older adults. The research utilizes advanced molecular techniques to analyze brain samples and assess the impact of environmental toxins.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that mitigate the effects of environmental factors on Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the impact of environmental factors on neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Lipton, Stuart a — Scripps Research Institute, the
- Study coordinator: Lipton, Stuart a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.