Investigating how air pollution affects metabolism and chronic diseases
Targets and targeting of immunometabolism in chronic PM2.5 exposure
This study is looking at how tiny air pollution particles can affect people with Type 2 diabetes and heart problems, hoping to find out how they might make these conditions worse and discover new ways to help manage them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11210632 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of PM2.5 air pollution on chronic diseases, particularly Type 2 diabetes and cardiovascular conditions. By studying both animal models and human subjects, the researchers aim to uncover the biological mechanisms through which air pollution contributes to inflammation and metabolic dysfunction. The project will involve detailed assessments of how exposure to PM2.5 alters metabolic pathways and increases disease risk, potentially leading to new therapeutic targets for managing these health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Type 2 diabetes or those at risk for cardiovascular disease due to environmental factors.
Not a fit: Patients without any chronic diseases or those not exposed to significant air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating chronic diseases linked to air pollution exposure.
How similar studies have performed: Previous studies have shown significant links between air pollution and chronic diseases, indicating that this research builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Maiseyeu, Andrei — Case Western Reserve University
- Study coordinator: Maiseyeu, Andrei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.