Investigating how air pollution affects metabolism and chronic diseases
Targets and targeting of immunometabolism in chronic PM2.5 exposure
This study is looking at how tiny air pollution particles called PM2.5 might affect people with chronic conditions like Type 2 diabetes and heart disease, to help find ways to reduce their health risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10989940 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of PM2.5, a common air pollutant, on chronic diseases like Type 2 diabetes and cardiovascular conditions. By studying both animal models and human subjects, the research aims to uncover the biological mechanisms through which PM2.5 contributes to inflammation and metabolic disorders. The project will explore how these pollutants alter metabolic pathways and may lead to increased health risks, ultimately seeking to identify potential therapeutic targets to mitigate these effects.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals with chronic conditions such as Type 2 diabetes or cardiovascular disease, particularly those living in areas with high levels of air pollution.
Not a fit: Patients without chronic diseases or those living in low pollution areas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating chronic diseases linked to air pollution exposure.
How similar studies have performed: Previous research has shown significant links between air pollution and chronic diseases, indicating that this approach is grounded in established findings.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Maiseyeu, Andrei — Case Western Reserve University
- Study coordinator: Maiseyeu, Andrei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.