Investigating how air pollution affects immune cells and Alzheimer's disease.
The Role of Peripheral Immune Cell Trafficking in Ozone-Induced Alzheimer's Disease Neuropathology
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11291352
This study is looking at how breathing in ozone from air pollution might be linked to Alzheimer's disease by seeing if it affects immune cells in the body and leads to changes in the brain that could cause the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11291352 on ClinicalTrials.gov |
What this research studies
This research explores the connection between ozone exposure from air pollution and the development of Alzheimer's disease (AD). It focuses on how inhaling ozone may trigger immune responses that could lead to increased amyloid plaque formation in the brain, a hallmark of AD. By studying the role of peripheral immune cells, such as neutrophils, the research aims to uncover the mechanisms by which air pollution contributes to AD pathology. This could involve examining changes in immune cell behavior and their impact on brain health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for Alzheimer's disease, particularly those living in areas with high levels of air pollution.
Not a fit: Patients who do not have a risk of developing Alzheimer's disease or who are not exposed to significant air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the effects of air pollution on immune responses.
How similar studies have performed: Previous research has indicated a link between air pollution and increased Alzheimer's risk, suggesting that this approach may yield valuable insights into disease mechanisms.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OBLAK, ADRIAN LYNN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: OBLAK, ADRIAN LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome