Investigating how air pollution affects allergic lung inflammation
Official title: Targeting Type-2 mucoinflammatory axis during the resolution of allergic lung inflammation
Funded at North Carolina State University Raleigh · NIH-11013297 · Data updated 2026-11-12
This study is looking at how air pollution, especially ozone, affects people with allergic asthma and how a molecule called IL-33 might play a role in keeping their lungs inflamed, with the hope of finding new ways to help ease their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | January 22, 2024 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $558,696 |
| NIH project number | 5R01ES035439-02 |
| Project ID | NIH-11013297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with allergic asthma, particularly those affected by air pollution.
✕Less likely to help
Patients with non-allergic asthma or those whose asthma is not influenced by environmental factors may not benefit from this research.
What this research studies
This research focuses on understanding how ozone pollution impacts the resolution of allergic asthma, particularly through the role of a molecule called IL-33. By studying the interactions between allergens and air pollution, the researchers aim to uncover the mechanisms that lead to persistent inflammation in the lungs. The approach involves advanced techniques to analyze cellular responses and signaling pathways involved in allergic reactions. Patients with allergic asthma may find this research relevant as it seeks to identify new ways to alleviate their symptoms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help resolve allergic inflammation in asthma patients more effectively.
How similar studies have gone: Previous research has shown promising results in targeting inflammatory pathways in asthma, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Saini, Yogesh — North Carolina State University Raleigh
- Study coordinator: Saini, Yogesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.