Investigating how aging cells in prostate tissue affect cancer progression
Official title: Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy
Funded at Johns Hopkins University · NIH-11015824 · Data updated 2026-11-12
This study is looking at how certain aging cells in the body might help make prostate cancer more aggressive, and it's for men with prostate cancer who want to understand more about what might be happening in their bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $262,383 |
| NIH project number | 5R01CA255349-05 |
| Project ID | NIH-11015824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with intermediate to high-risk prostate cancer.
✕Less likely to help
Patients with low-risk prostate cancer or those without prostate cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of senescent stromal fibroblasts in the progression of lethal prostate cancer. It examines how these aging cells, which may trigger inflammation, contribute to the development of aggressive cancer in men. By analyzing tissue samples from prostate cancer patients, the study aims to identify specific markers associated with these fibroblasts and their relationship to cancer severity. The approach includes a multi-marker strategy to differentiate between normal and senescent fibroblasts and assess their impact on cancer outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new prognostic tools and therapeutic targets for men with prostate cancer.
How similar studies have gone: Previous research has shown promising results in targeting cellular senescence in cancer, indicating potential for success in this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Platz, Elizabeth a. — Johns Hopkins University
- Study coordinator: Platz, Elizabeth a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.