Investigating how aging cells contribute to uterine fibroids
Role of senescent cells in uterine fibroid pathogenesis
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11051138
This study is looking at how aging cells in the body might play a part in the growth of uterine fibroids, which many women experience and can lead to problems like heavy bleeding and difficulty getting pregnant, with hopes of finding new, non-surgical treatments to help.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11051138 on ClinicalTrials.gov |
What this research studies
This research explores the role of senescent cells in the development of uterine fibroids, which are common among women and can cause significant health issues like heavy bleeding and infertility. By utilizing advanced techniques such as single-cell RNA sequencing, the study aims to understand how these aging cells interact with immune cells and contribute to the fibrotic environment of fibroids. The findings could lead to new non-surgical treatment options for women suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with uterine fibroids who experience symptoms such as heavy menstrual bleeding or pelvic pain.
Not a fit: Patients without uterine fibroids or those who have already undergone surgical treatment for fibroids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into non-surgical treatments for uterine fibroids, potentially alleviating symptoms and improving quality of life for affected women.
How similar studies have performed: Previous research has shown promising results regarding the role of senescent cells in other fibrotic conditions, suggesting that this approach may yield valuable insights for uterine fibroids as well.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEGARS, JAMES H. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SEGARS, JAMES H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.