Investigating how aging cells contribute to uterine fibroids
Official title: Role of senescent cells in uterine fibroid pathogenesis
Funded at Johns Hopkins University · NIH-11051138 · Data updated 2026-11-12
This study is looking at how aging cells in the body might play a part in the growth of uterine fibroids, which many women experience and can lead to problems like heavy bleeding and difficulty getting pregnant, with hopes of finding new, non-surgical treatments to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $791,630 |
| NIH project number | 5R01HD111243-03 |
| Project ID | NIH-11051138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with uterine fibroids who experience symptoms such as heavy menstrual bleeding or pelvic pain.
✕Less likely to help
Patients without uterine fibroids or those who have already undergone surgical treatment for fibroids may not benefit from this research.
What this research studies
This research explores the role of senescent cells in the development of uterine fibroids, which are common among women and can cause significant health issues like heavy bleeding and infertility. By utilizing advanced techniques such as single-cell RNA sequencing, the study aims to understand how these aging cells interact with immune cells and contribute to the fibrotic environment of fibroids. The findings could lead to new non-surgical treatment options for women suffering from this condition.
Why it matters
Potential benefit: If successful, this research could provide new insights into non-surgical treatments for uterine fibroids, potentially alleviating symptoms and improving quality of life for affected women.
How similar studies have gone: Previous research has shown promising results regarding the role of senescent cells in other fibrotic conditions, suggesting that this approach may yield valuable insights for uterine fibroids as well.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Segars, James H. — Johns Hopkins University
- Study coordinator: Segars, James H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.