Investigating how aging cells contribute to Parkinson's disease in the brain
Molecular Assessment of Cause and Consequence of Cellular Senescence in Diverse Midbrain Cell Types in Parkinson's Disease
This study is looking at how certain brain cells change as we age and how that might lead to problems in Parkinson's disease, with the hope of finding new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10872261 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cellular senescence, a process where cells stop dividing and can contribute to inflammation, in the development of Parkinson's disease. Researchers will study different types of brain cells, particularly dopaminergic neurons, to identify triggers that lead to cellular senescence and how this affects immune responses in the brain. By examining human and mouse models, the study aims to uncover the mechanisms behind neuron loss in Parkinson's disease, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Parkinson's disease or are at risk for developing it.
Not a fit: Patients who are younger than 65 or do not have any symptoms or risk factors for Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown that targeting cellular senescence can have beneficial effects in other neurodegenerative conditions, suggesting potential for success in this area as well.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Riessland, Markus — State University New York Stony Brook
- Study coordinator: Riessland, Markus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.