Investigating how aging cells contribute to inflammation in Alzheimer's disease
Endogenous drivers of endothelial inflammation in Alzheimer's Disease
This study is looking at how certain aging cells in the body might affect blood flow in the brains of people with Alzheimer's, and it hopes to find ways to improve brain health by targeting these cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10996814 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of senescent cells, which accumulate as we age, in the progression of Alzheimer's disease. By analyzing data from both human and mouse models, the study aims to identify specific molecular patterns in these aging cells that may disrupt healthy brain blood vessels. The goal is to explore how targeting these patterns could potentially alleviate inflammation and improve vascular function in Alzheimer's patients. This approach combines advanced genetic analysis with insights into cellular behavior in the context of aging and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with early-stage Alzheimer's disease who do not exhibit signs of vascular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain health and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells in other age-related diseases, suggesting potential for success in this novel approach to Alzheimer's disease.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Sanborn, Mark Allen — University of Illinois at Chicago
- Study coordinator: Sanborn, Mark Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.