Investigating how aging cells contribute to inflammation in Alzheimer's disease
Official title: Endogenous drivers of endothelial inflammation in Alzheimer's Disease
Funded at University of Illinois at Chicago · NIH-10996814 · Data updated 2026-11-12
This study is looking at how certain aging cells in the body might affect blood flow in the brains of people with Alzheimer's, and it hopes to find ways to improve brain health by targeting these cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 16, 2024 |
| Project end | August 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG090005-01 |
| Project ID | NIH-10996814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
✕Less likely to help
Patients with early-stage Alzheimer's disease who do not exhibit signs of vascular dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of senescent cells, which accumulate as we age, in the progression of Alzheimer's disease. By analyzing data from both human and mouse models, the study aims to identify specific molecular patterns in these aging cells that may disrupt healthy brain blood vessels. The goal is to explore how targeting these patterns could potentially alleviate inflammation and improve vascular function in Alzheimer's patients. This approach combines advanced genetic analysis with insights into cellular behavior in the context of aging and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain health and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting senescent cells in other age-related diseases, suggesting potential for success in this novel approach to Alzheimer's disease.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Sanborn, Mark Allen — University of Illinois at Chicago
- Study coordinator: Sanborn, Mark Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.