Investigating how aging cells contribute to Alzheimer's disease
Effects of senescence to AlzheimerâÂÂs disease pathology
This study is looking at how old cells in the brain might play a role in Alzheimer's disease, and it hopes to find ways to get rid of these cells to help improve thinking and memory for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10886024 on NIH RePORTER |
What this research studies
This research explores the role of senescent cells, which accumulate as we age, in the development of Alzheimer's disease. By examining how these aging cells contribute to neurodegenerative processes, the study aims to identify potential therapeutic strategies to remove these cells and mitigate disease severity. The approach involves using established models of neurodegeneration to test whether eliminating senescent cells can improve cognitive function and reduce the impact of Alzheimer's pathology. Patients may benefit from insights gained into how aging affects brain health and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells for various age-related conditions, suggesting potential for success in this area as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Baker, Darren — Mayo Clinic Rochester
- Study coordinator: Baker, Darren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.