Investigating how aging cells affect brain health
Project 3 - Cellular Senescence and Brain Aging
This study is looking at how aging cells in the brain might be linked to memory loss and thinking problems, and it aims to find ways to help keep our brains healthier as we get older.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11079530 on NIH RePORTER |
What this research studies
This research explores the connection between aging cells and cognitive decline in the brain. It focuses on a phenomenon called cellular senescence, where cells lose their ability to function properly as they age. By using advanced mouse models and innovative techniques, the researchers aim to understand how these aging cells contribute to memory loss and other cognitive issues. The goal is to find ways to target and eliminate these senescent cells to promote healthier brain aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or memory issues.
Not a fit: Patients who are not experiencing age-related cognitive decline or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and overall brain health in older adults.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells to improve health outcomes, indicating potential success for this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Jurk, Diana — Mayo Clinic Rochester
- Study coordinator: Jurk, Diana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.