Investigating how aging and PTSD affect brain function in older adults
Aging, PTSD, and the Anterior Cingulate Cortex (ACC)
This study is looking at how aging and PTSD affect a part of the brain that helps with thinking and attention, especially in older adults who don’t have early signs of Alzheimer’s, to find ways to keep their minds sharp and healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Minneapolis VA Medical Center NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10862565 on NIH RePORTER |
What this research studies
This research explores the relationship between aging, post-traumatic stress disorder (PTSD), and the anterior cingulate cortex (ACC), a brain region important for attention and executive functions. It aims to understand how metabolic decline in the ACC correlates with cognitive aging and stress, particularly in older adults without preclinical Alzheimer's disease. Using advanced imaging techniques, the study will measure oxidative stress and assess cognitive functions through neuropsychological testing. The goal is to identify potential biomarkers and mechanisms that could lead to new strategies for maintaining cognitive health in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those with a history of PTSD but without signs of preclinical Alzheimer's disease.
Not a fit: Patients who are younger than 65 or those already diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for cognitive decline in older adults, particularly those affected by PTSD.
How similar studies have performed: Similar research has shown promising results in understanding the effects of stress on cognitive aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- Minneapolis VA Medical Center — Minneapolis, United States (Active)
Researchers
- Principal investigator: Pardo, Jose V — Minneapolis VA Medical Center
- Study coordinator: Pardo, Jose V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.