Investigating how aging and high blood pressure affect bone health
Official title: Common Inflammation Pathways between Aging and Hypertension That Weaken Bone
Funded at Vanderbilt University Medical Center · NIH-11054626 · Data updated 2026-11-12
This study is looking at how getting older and having high blood pressure can affect bone health, especially in relation to osteoporosis, and it's for older adults who want to understand how these factors might impact their bones and explore new ways to keep them strong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 15, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $453,730 |
| NIH project number | 5R01AG076785-04 |
| Project ID | NIH-11054626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those with hypertension or at risk for osteoporosis.
✕Less likely to help
Patients who are younger than 21 or do not have hypertension or osteoporosis may not benefit from this research.
What this research studies
This research explores the connection between aging, hypertension, and bone health, particularly focusing on how these factors contribute to osteoporosis. The study aims to identify common molecular pathways that lead to weakened bones in older adults with high blood pressure. By using animal models and cell culture experiments, researchers will examine how elevated blood pressure and inflammation impact bone strength and the potential for new treatment strategies. The ultimate goal is to develop better detection and treatment methods for osteoporosis in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating osteoporosis in older adults, reducing the risk of fractures.
How similar studies have gone: Previous research has shown promising results in understanding the links between hypertension and bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Harrison, David G — Vanderbilt University Medical Center
- Study coordinator: Harrison, David G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.