Investigating how aging affects the retina and visual cortex differently in men and women
Official title: Sex-dependent aging mechanisms of retina and visual cortex
Funded at Georgetown University · NIH-10878520 · Data updated 2026-11-12
This study is looking at how getting older affects our eyesight, especially for those with age-related macular degeneration (AMD), and it aims to find new treatments that could help, particularly for women who are more affected by this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $247,033 |
| NIH project number | 1R21AG086982-01 |
| Project ID | NIH-10878520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly women, who are at risk for or experiencing symptoms of age-related macular degeneration.
✕Less likely to help
Patients who are younger or do not have any visual impairments related to aging may not benefit from this research.
What this research studies
This research explores the impact of aging on the visual system, focusing on how changes in the retina and visual cortex can lead to conditions like age-related macular degeneration (AMD), a leading cause of blindness in older adults. The study examines the role of retinal pigment epithelium (RPE) in maintaining photoreceptors and how sex differences may influence the progression of AMD. By understanding these mechanisms, the research aims to identify potential new therapies for AMD, particularly for the more affected female population. Patients may be involved in assessments that help clarify the relationship between aging, sex hormones, and visual health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related macular degeneration, potentially improving vision and quality of life for older adults.
How similar studies have gone: Previous research has indicated sex differences in the prevalence and progression of age-related macular degeneration, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Golestaneh, Nady — Georgetown University
- Study coordinator: Golestaneh, Nady
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.