Investigating how aging affects the intestines in a small worm model.
Tissue Mechanisms of Aging in the Genetic Model C. elegans
This study is looking at tiny worms to learn how their intestines change as they get older, which could help us understand what keeps them healthy as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10942627 on NIH RePORTER |
What this research studies
This research focuses on the nematode C. elegans, a small worm that serves as a model for studying aging. The project aims to understand how the intestines of these worms respond to cellular stress as they age, particularly looking at changes in the structure and function of intestinal cells. By examining the early signs of aging in the intestines, researchers hope to identify critical factors that contribute to healthy lifespan. The study employs genetic and cellular techniques to analyze the deterioration of intestinal nuclei and their implications for aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may have conditions related to aging.
Not a fit: Patients with acute or severe health conditions unrelated to aging mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to insights that improve our understanding of aging and potentially inform strategies to promote healthier aging in humans.
How similar studies have performed: Previous research using C. elegans as a model for aging has shown promising results, indicating that this approach is well-established and has the potential for significant findings.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Priess, James R — Fred Hutchinson Cancer Center
- Study coordinator: Priess, James R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.