Investigating how aging affects the connection between bones and the brain
Role of Cellular Senescence in the Bone-Brain Interplay
This study is looking at how bone health might affect brain function in older adults and people with Alzheimer's, hoping to find new ways to help with memory and thinking problems as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10860932 on NIH RePORTER |
What this research studies
This research explores the relationship between bone health and brain function, particularly in older adults and those with Alzheimer's disease. It examines how aging and the presence of certain cells in the bone may influence blood flow and the integrity of the blood-brain barrier. By studying these interactions, the research aims to uncover mechanisms that could lead to new treatments for age-related cognitive decline and dementia. The approach involves analyzing cellular changes and their effects on brain health in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger or do not have any cognitive impairments or bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and other forms of dementia by targeting bone health.
How similar studies have performed: Previous research has indicated potential links between bone health and brain function, suggesting that this area of investigation could yield significant insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wan, Mei — Johns Hopkins University
- Study coordinator: Wan, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.