Investigating how aging affects neural stem cells and neurodegeneration
Official title: Neural Stem Cell Aging and Neurodegeneration
Funded at University of California Berkeley · NIH-11037927 · Data updated 2026-11-12
This study is looking at how stress in tiny energy factories in our cells affects aging brain cells and their link to diseases like Alzheimer's, and it hopes to find ways to help older adults stay healthier and think better by using a special cellular response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | March 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $487,635 |
| NIH project number | 5R01AG082105-02 |
| Project ID | NIH-11037927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older, especially those experiencing early signs of cognitive decline or neurodegenerative conditions.
✕Less likely to help
Patients under the age of 65 or those without any signs of neurodegenerative diseases may not benefit from this research.
What this research studies
This research explores the impact of mitochondrial stress on neural stem cell aging and its connection to neurodegenerative diseases like Alzheimer's. By activating a specific cellular response known as the mitochondrial unfolded protein response (UPRmt), the study aims to understand how this process can improve health and lifespan in older adults. The researchers will use advanced techniques to manipulate these pathways in order to potentially enhance tissue health and combat age-related diseases. The findings could lead to new therapeutic strategies for maintaining cognitive function in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health and cognitive function in older adults, particularly those at risk for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in manipulating mitochondrial responses to extend lifespan and improve health in model organisms, suggesting potential for success in this area.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Chen, Danica — University of California Berkeley
- Study coordinator: Chen, Danica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.