Investigating how aging affects mutations in brain cells related to Alzheimer's disease
Spatial single-cell analysis of somatic mutation in human brain during aging and neurodegeneration
['FUNDING_OTHER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10687449
This study is looking at how changes in brain cells might play a role in aging and diseases like Alzheimer's, with the hope of finding new ways to help people affected by these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10687449 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how somatic mutations in brain cells contribute to aging and neurodegeneration, particularly in Alzheimer's disease. By utilizing advanced single-cell sequencing techniques, the study aims to identify and characterize these mutations at a cellular level, which could reveal important insights into the mechanisms of neuron loss. Patients may benefit from this research as it seeks to uncover the genetic factors that accelerate neurodegeneration, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with early-onset dementia not related to Alzheimer's or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding genetic mutations in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LODATO, MICHAEL ANTHONY — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: LODATO, MICHAEL ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease