Investigating how aging affects metabolism in tumors and their surroundings
Determining Age-Dependent Metabolic Changes in Tumors and Their Microenvironment
This study is looking at how getting older affects the way tumors grow and change, especially by looking at how our diet and gut health might play a role, to help us understand cancer better in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11134805 on NIH RePORTER |
What this research studies
This research explores the relationship between aging and metabolic changes in tumors, aiming to understand how these changes contribute to cancer development and progression. By using animal models, the study will examine how age-related metabolic alterations impact both tumor cells and the surrounding microenvironment. The researchers will employ a detailed, single-cell approach to identify these metabolic changes over time and assess the influence of environmental factors, such as diet and microbiome metabolites, on cancer behavior. This comprehensive analysis could provide insights into the mechanisms of cancer in older populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or currently diagnosed with cancer.
Not a fit: Patients who are younger and do not have cancer or are not at risk for cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cancer in older adults by targeting age-related metabolic changes.
How similar studies have performed: While there has been some research on cancer metabolism, this specific focus on age-dependent metabolic changes in tumors is relatively novel and has not been extensively tested.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Mihaylova, Maria M. — Ohio State University
- Study coordinator: Mihaylova, Maria M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.