Investigating how aging affects metabolism and immune function in people living with HIV
Official title: Metabolic deficits and immune dysfunction in aging people living with HIV
Funded at University of Miami School of Medicine · NIH-11008239 · Data updated 2026-11-12
This study is looking at how getting older affects the metabolism and immune system of people living with HIV, especially how chronic inflammation can make these issues worse, and it aims to help us understand the connection between aging, immune health, and metabolism in this group.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $619,511 |
| NIH project number | 1R01AG086071-01A1 |
| Project ID | NIH-11008239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults living with HIV who may be experiencing immune dysfunction and metabolic changes.
✕Less likely to help
Patients who are not living with HIV or who are younger and not experiencing age-related metabolic issues may not benefit from this research.
What this research studies
This research explores the impact of aging on metabolic and immune changes in individuals living with HIV. It focuses on understanding how chronic inflammation and immune activation, common in both aging and HIV, lead to impaired immune responses and metabolic dysfunction. The study will analyze blood metabolites related to glucose and fatty acid metabolism and their association with immune cell function. By examining these relationships, the research aims to uncover how aging exacerbates immune deficiencies in people living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing immune health and metabolic function in aging individuals with HIV.
How similar studies have gone: Previous research has indicated that metabolic and immune dysfunctions are interconnected in aging populations, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Frasca, Daniela — University of Miami School of Medicine
- Study coordinator: Frasca, Daniela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.