Investigating how aging affects inflammation and metabolism in the body
Official title: Tissue senescence and age-associated metabolic dysfunction: the role of immune cell mediated inflammation
Funded at University of Utah · NIH-11009553 · Data updated 2026-11-12
This study looks at how aging and inflammation affect metabolism, especially by examining how certain aging cells can cause inflammation in older adults, with the goal of finding new ways to help improve health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | March 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $401,253 |
| NIH project number | 5R01AG076748-03 |
| Project ID | NIH-11009553 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing metabolic dysfunction or related age-associated conditions.
✕Less likely to help
Patients who are younger or do not have any age-related metabolic issues may not benefit from this research.
What this research studies
This research explores the relationship between aging, inflammation, and metabolic dysfunction. It focuses on how senescent cells, which are cells that have stopped dividing due to age-related stress, release inflammatory substances that can disrupt normal metabolism. By studying immune cell behavior in older individuals, the research aims to uncover mechanisms that lead to chronic inflammation and metabolic issues. The findings could help identify new therapeutic strategies to improve health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve metabolic health in older adults.
How similar studies have gone: Other research has shown promising results in understanding the role of inflammation in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Lesniewski, Lisa a — University of Utah
- Study coordinator: Lesniewski, Lisa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.