Investigating how aging affects heart inflammation and injury during surgery
MIF and Cardiovascular Inflammation
This study is looking at how getting older affects how your body handles stress from surgery, especially for people over 60, by exploring a specific pathway that helps manage inflammation and stress in blood vessels, to better understand why older adults might face more complications after heart procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10863883 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging impacts the body's response to surgical stress, particularly in patients over 60 years old. It examines the role of a specific signaling pathway, the MIF-AMPK cascade, which is crucial for managing inflammation and oxidative stress in blood vessels. By studying how this pathway functions in older adults, the research aims to uncover why they are more susceptible to complications after cardiac procedures. The approach involves analyzing cellular responses to stress and inflammation in the context of atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly patients, particularly those over 60 years old, who are scheduled for cardiac surgery or have atherosclerosis.
Not a fit: Patients under 60 years old or those without cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing complications in elderly patients undergoing cardiac surgery.
How similar studies have performed: Previous research has shown that understanding cellular stress responses can lead to significant advancements in managing surgical outcomes, indicating potential success for this approach.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Li, Ji — University of Mississippi Med Ctr
- Study coordinator: Li, Ji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.