Investigating how aging affects brain function related to memory and learning.
CaMKII nitrosylation in the age-related decline of synaptic plasticity
This study is looking at how changes in the brain as we age can affect memory and thinking, especially in people with Alzheimer's disease, and it hopes to find new ways to help improve brain function by focusing on a specific protein involved in memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10896339 on NIH RePORTER |
What this research studies
This research focuses on understanding how age-related changes in brain function contribute to cognitive decline, particularly in conditions like Alzheimer's disease. The study examines the role of a specific protein, CaMKII, in synaptic function, which is crucial for memory and learning. By comparing the mechanisms of synaptic impairment in normal aging versus Alzheimer's, the researchers aim to identify potential targets for therapeutic intervention. Patients may benefit from insights that could lead to new treatments for cognitive decline associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with cognitive decline due to non-age-related factors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding synaptic function and its implications for cognitive decline, making this approach both relevant and potentially impactful.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bayer, K. Ulrich — University of Colorado Denver
- Study coordinator: Bayer, K. Ulrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.