Investigating how aging affects brain cell structure in older adults
Single-Cell Analysis of Aging-Associated 4D Nucleome in the Human Hippocampus
This study is looking at how aging affects brain cells, especially in the part of the brain that helps with memory, and it wants to see if staying active can help keep our brain's DNA organized and functioning well as we get older.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10914832 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular changes that occur in brain cells as people age, particularly in the hippocampus, which is crucial for memory and learning. By examining post-mortem brain tissue from individuals aged 65 and older, the study aims to identify how physical activity influences the organization of the nucleome, which is the 3D structure of DNA within cells. Using advanced techniques like Methyl-HiC and Paired-seq, researchers will analyze how these changes impact brain function and cognitive health. This work could provide insights into maintaining cognitive abilities in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those who are physically active or have experienced cognitive decline.
Not a fit: Patients under the age of 65 or those with non-age-related cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving cognitive function and preventing memory decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding brain aging and the effects of physical activity on cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Xu, Xiangmin — University of California-Irvine
- Study coordinator: Xu, Xiangmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.