Investigating how aging affects bone regeneration in the mouth
Aging and dysfunction of progenitor niches: Role of Del-1
This study is looking into why older adults are more likely to have gum disease and how a protein called Del-1 affects their ability to heal, with hopes of finding better treatments for healthier gums as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10754857 on NIH RePORTER |
What this research studies
This research focuses on understanding why older adults are more susceptible to periodontitis, an inflammatory disease that damages the tissues supporting teeth. It explores how aging alters the immune response and the regenerative capacity of periodontal tissues, particularly through the role of a protein called Del-1. By studying animal models, the research aims to uncover how Del-1 deficiency in older individuals contributes to poor bone regeneration in the mouth, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing periodontal issues or those at risk for periodontitis.
Not a fit: Patients who are not elderly or do not have periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease in older adults, enhancing their oral health and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteins like Del-1 in tissue regeneration, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hajishengallis, Georgios — University of Pennsylvania
- Study coordinator: Hajishengallis, Georgios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.