Investigating how aging affects blood vessel formation
Endothelial extracellular vesicles in aging
['FUNDING_R21'] · MEDICAL COLLEGE OF WISCONSIN · NIH-10984795
This study is looking at how getting older affects the body's ability to create new blood vessels, which are important for healing and keeping organs healthy, and it focuses on tiny particles that help carry signals between cells to see how they change with age, hoping to find ways to improve health for older adults.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10984795 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how aging impacts the formation of new blood vessels, a process crucial for organ repair and function. It examines the role of extracellular vesicles, which are tiny particles released by cells that carry important signals, in mediating the effects of aging on blood vessel development. By studying these vesicles in aged and young animals, the research aims to uncover mechanisms that contribute to age-related diseases and impaired healing. The ultimate goal is to identify potential therapeutic targets to improve health outcomes in the aging population.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues, particularly those related to cardiovascular diseases.
Not a fit: Patients who are younger and do not have age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance blood vessel formation and improve health in older adults.
How similar studies have performed: Previous research has shown that targeting mechanisms of angiogenesis can lead to significant improvements in age-related health conditions, indicating a promising avenue for this investigation.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAMMOTO, AKIKO — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MAMMOTO, AKIKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiovascular Diseases