Investigating how aging affects blood vessel formation
Official title: Endothelial extracellular vesicles in aging
Funded at Medical College of Wisconsin · NIH-10984795 · Data updated 2026-11-12
This study is looking at how getting older affects the body's ability to create new blood vessels, which are important for healing and keeping organs healthy, and it focuses on tiny particles that help carry signals between cells to see how they change with age, hoping to find ways to improve health for older adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $418,000 |
| NIH project number | 1R21AG084736-01A1 |
| Project ID | NIH-10984795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues, particularly those related to cardiovascular diseases.
✕Less likely to help
Patients who are younger and do not have age-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how aging impacts the formation of new blood vessels, a process crucial for organ repair and function. It examines the role of extracellular vesicles, which are tiny particles released by cells that carry important signals, in mediating the effects of aging on blood vessel development. By studying these vesicles in aged and young animals, the research aims to uncover mechanisms that contribute to age-related diseases and impaired healing. The ultimate goal is to identify potential therapeutic targets to improve health outcomes in the aging population.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance blood vessel formation and improve health in older adults.
How similar studies have gone: Previous research has shown that targeting mechanisms of angiogenesis can lead to significant improvements in age-related health conditions, indicating a promising avenue for this investigation.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Mammoto, Akiko — Medical College of Wisconsin
- Study coordinator: Mammoto, Akiko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.