Investigating how aging affects attention and distractibility in the brain
Losing specificity: the role of the locus coeruleus in age-related distractibility
This study is looking at how our brains change as we get older and why it can be harder to focus when there are distractions, especially by examining a specific brain area called the locus coeruleus, and it’s for older adults who want to understand more about attention and aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10898858 on NIH RePORTER |
What this research studies
This research explores the neural mechanisms behind age-related distractibility, particularly focusing on a brain region called the locus coeruleus. By using advanced imaging techniques and animal models, the study aims to understand how changes in brain connectivity affect older adults' ability to focus amidst distractions. The researchers will manipulate neural circuits in animals and analyze how these changes impact attention performance, while also examining similar patterns in human participants. This integrative approach seeks to uncover the biological underpinnings of cognitive decline associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related cognitive decline or distractibility.
Not a fit: Patients with early-stage Alzheimer's disease or other forms of dementia may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving attention and cognitive function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding brain connectivity and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Lee, Tae-Ho — Virginia Polytechnic Inst and St Univ
- Study coordinator: Lee, Tae-Ho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.