Investigating how aging affects Alzheimer's disease drivers
The complex interaction between Alzheimer drivers and aging
This study is looking at how aging and certain genetic factors affect Alzheimer's disease, especially in younger people, to better understand what causes it and how things like inflammation and brain health play a role, so we can help everyone impacted by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-10875705 on NIH RePORTER |
What this research studies
This research explores the relationship between aging and the factors that drive Alzheimer's disease. By examining cases of early onset Alzheimer's from a Colombian brain bank, the study aims to identify the full range of pathology associated with a specific genetic mutation. It will compare these findings with sporadic cases of Alzheimer's in older individuals, focusing on how inflammation, brain vasculature, and cellular aging contribute to the disease. Advanced techniques like single-cell RNA sequencing and inflammation marker assessments will be utilized to gain deeper insights into these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with early onset Alzheimer's disease or those at risk for sporadic Alzheimer's due to aging.
Not a fit: Patients with non-Alzheimer's related dementia or those without any risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's disease, particularly in older patients.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's pathology through genetic and aging perspectives, indicating that this approach has potential for success.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Kosik, Kenneth Stephen — University of California Santa Barbara
- Study coordinator: Kosik, Kenneth Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.