Investigating how age-related blood cell changes affect exercise response and heart health
Official title: Age-Related Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Exercise Responsiveness
Funded at Duke University · NIH-10950685 · Data updated 2026-11-12
This study is looking at how a condition called CHIP, which can happen as we age and is linked to heart health, affects how well people respond to exercise, with the goal of finding ways to help personalize fitness plans to keep hearts healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $104,933 |
| NIH project number | 1K38HL175026-01 |
| Project ID | NIH-10950685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are at risk for cardiovascular disease and have a history of sedentary lifestyle or metabolic issues.
✕Less likely to help
Patients who are younger and do not have risk factors for cardiovascular disease may not receive benefit from this research.
What this research studies
This research explores the relationship between age-related clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular health, particularly how it affects exercise responsiveness. The study aims to understand how CHIP, which is linked to inflammation and cardiovascular disease, may influence an individual's ability to benefit from chronic exercise training. By identifying metabolic biomarkers associated with both CHIP and cardiovascular fitness, the research seeks to personalize care strategies for preventing cardiovascular disease. Participants may undergo assessments to evaluate their cardiovascular fitness and response to exercise interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved personalized exercise recommendations for better cardiovascular health in older adults.
How similar studies have gone: Previous research has shown that chronic exercise can reduce inflammation and improve cardiovascular outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Regan, Jessica Ann — Duke University
- Study coordinator: Regan, Jessica Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.